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KMID : 0882419770200111037
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Korean Journal of Medicine
1977 Volume.20 No. 11 p.1037 ~ p.1044
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Two Cases of Angio - immunoblastic Lymphadenopathy with Dysproteinemia
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Kang Jin-Yung
Park Jung-Sik
Byeon Chong-Hoon
Park Seon-Yang
Kwon In-Soon
Choi Kyoo-Wan
Lee Mun-Ho
Song Kye-Yong
Kim Yong-Il
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Abstract
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Two cases of Angio-immunoblastic Lymphadenopathy with Dysproteinemia (AILD) are presented with brief review. Forty five year old female was admitted to Seoul National University Hospital with generalized lymphadenopathy and severe constitutional symptom, and fifty one year old male was admitted with intermittent high fever and generalized lymphadenopathy and severe constitutional symptoms. Various laboratory studies including lymphnode biopsy, confirmed that these clinical findings were due to new clinico-patholgic entity, AILD which is characterized by 1) mixed cellular proliferation with prominent immunoblastic content, 2) vascular proliferation, 3) extensive alteration of the nodal architecture, and 4) the presence of acidophilic interstitial material, in lymphnode. The clinical, laboratory and pathologic manifestations of AILD are consistent with an autoimmune disorder, in which a deficiency of the T-cell regulatory functions probably predispose to an abnormal proliferation and auto aggressive reaction of B-cell.
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KEYWORD
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